Using fecal microbiota transplant to treat alcohol-related liver disease
Fecal microbiota transplant for Alcohol-Associated Cirrhosis
['FUNDING_R01'] · VIRGINIA COMMONWEALTH UNIVERSITY · NIH-10912532
This study is looking at whether a special treatment using gut bacteria from healthy donors can help people with liver damage from alcohol by reducing their cravings for alcohol and improving their health.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VIRGINIA COMMONWEALTH UNIVERSITY (nih funded) |
| Locations | 1 site (RICHMOND, UNITED STATES) |
| Trial ID | NIH-10912532 on ClinicalTrials.gov |
What this research studies
This research investigates the use of fecal microbiota transplant (FMT) as a treatment for patients with alcohol-associated cirrhosis. The study aims to restore the balance of gut bacteria, which can be disrupted by alcohol consumption, and assess its effects on reducing alcohol cravings and improving overall health. Participants will receive a standardized oral encapsulated FMT preparation in a controlled clinical trial to evaluate its safety and efficacy compared to a placebo. The research builds on previous findings that suggest FMT can positively influence alcohol consumption and cognitive health in affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with alcohol-associated cirrhosis who are actively consuming alcohol.
Not a fit: Patients with other forms of liver disease unrelated to alcohol or those who are not currently consuming alcohol may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a new therapeutic option for patients struggling with alcohol use disorder and liver disease.
How similar studies have performed: Previous studies have shown promising results with fecal microbiota transplant in similar contexts, indicating potential for success in this novel application.
Where this research is happening
RICHMOND, UNITED STATES
- VIRGINIA COMMONWEALTH UNIVERSITY — RICHMOND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BAJAJ, JASMOHAN S — VIRGINIA COMMONWEALTH UNIVERSITY
- Study coordinator: BAJAJ, JASMOHAN S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alcohol-Induced Disorders