Using extracellular vesicles to treat kidney disease related to aging and diabetes
Official title: Extracellular vesicle-based senotherapeutics for aging diabetic kidneydisease
Funded at Mayo Clinic Jacksonville · NIH-11032015 · Data updated 2026-11-12
This study is looking at new treatments for diabetic kidney disease, which often affects older adults with diabetes and obesity, by using tiny particles from special cells that might help reduce inflammation and improve kidney health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Jacksonville NIH-funded |
| Lab location | 1 site (Jacksonville, United States) |
| Project start | June 1, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $521,046 |
| NIH project number | 5R01AG076537-03 |
| Project ID | NIH-11032015 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults with diabetes and obesity who are experiencing or at risk of diabetic kidney disease.
✕Less likely to help
Patients without diabetes or significant kidney issues may not benefit from this research.
What this research studies
This research focuses on developing new therapies to combat diabetic kidney disease (DKD) that often affects older adults with obesity and diabetes. It aims to reduce harmful inflammation and cellular aging in the kidneys by utilizing extracellular vesicles derived from mesenchymal stromal cells. These vesicles contain microRNAs that may help restore kidney function and improve overall health in aging populations. The study will explore how these therapies can halt the progression of DKD and enhance the quality of life for affected individuals.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that significantly improve kidney health and longevity for patients suffering from diabetic kidney disease.
How similar studies have gone: Previous research has shown promising results using similar approaches with extracellular vesicles in treating inflammatory and aging-related conditions.
Where this research is happening
-
Mayo Clinic Jacksonville
Jacksonville, United States Active
Researchers
- Principal investigator: Hickson, Latonya J — Mayo Clinic Jacksonville
- Study coordinator: Hickson, Latonya J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.