Using extracellular vesicles to treat age-related brain changes in primates
Extracellular Vesicle treatment and age-related neuropathology in non-human primates
This study is looking at how tiny particles released from cells might help improve memory and thinking skills in older monkeys by promoting brain health and repairing damage, and it could lead to new ways to support brain function as we age.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10830433 on NIH RePORTER |
What this research studies
This research investigates how extracellular vesicles, which are tiny particles released from cells, can help address cognitive decline associated with aging in non-human primates. The study focuses on understanding the effects of these vesicles on brain health, particularly in relation to myelin loss and inflammation, which are known to impact memory and executive function. By administering these vesicles, the researchers aim to see if they can improve cognitive function and promote brain repair processes. This approach builds on previous findings that suggest extracellular vesicles can enhance recovery after brain injuries.
Who could benefit from this research
Good fit: Ideal candidates for this research would be older adults experiencing cognitive decline or related neurological issues.
Not a fit: Patients with acute neurological conditions or those not experiencing age-related cognitive decline may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve cognitive function in aging individuals.
How similar studies have performed: Previous studies have shown that extracellular vesicles can improve cognitive deficits in animal models, suggesting potential for success in this novel application.
Where this research is happening
Boston, United States
- Boston University Medical Campus — Boston, United States (Active)
Researchers
- Principal investigator: Moore, Tara L — Boston University Medical Campus
- Study coordinator: Moore, Tara L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.