Using extracellular vesicles to improve diagnosis of severe allergic reactions
Official title: Extracellular Vesicles as Biomarkers of Immediate Hypersensitivity Reactions
Funded at Johns Hopkins University · NIH-11115745 · Data updated 2026-11-12
This study is looking at tiny particles in the blood called extracellular vesicles to see if they can help doctors quickly and accurately diagnose serious allergic reactions like anaphylaxis in adults who have had these reactions.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | June 13, 2024 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $286,563 |
| NIH project number | 5R21AI182531-02 |
| Project ID | NIH-11115745 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults who have experienced acute allergic reactions, particularly those with a history of anaphylaxis.
✕Less likely to help
Patients who do not have a history of allergic reactions or those under 21 years old may not benefit from this research.
What this research studies
This research investigates the use of extracellular vesicles (EVs) as potential biomarkers for diagnosing immediate hypersensitivity reactions, such as anaphylaxis. By analyzing patient samples from ongoing clinical trials, the study aims to characterize the quantity and content of EVs in adults who have experienced acute allergic reactions. The goal is to develop reliable and specific biomarkers that can aid in the accurate diagnosis and management of these life-threatening conditions.
Why it matters
Potential benefit: If successful, this research could lead to more accurate and timely diagnoses of anaphylaxis, improving patient outcomes and safety.
How similar studies have gone: Other research has shown promise in using biomarkers for allergic reactions, but the specific approach of using EVs in this context is relatively novel.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Dispenza, Melanie C. — Johns Hopkins University
- Study coordinator: Dispenza, Melanie C.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.