Using exosomes to improve delivery for heart and lung injury treatments
Harnessing Platelet-Endothelial Interactions for Exosome Delivery
This study is looking at how to make tiny particles called exosomes better at helping heal heart and lung injuries, especially after events like heart attacks, by ensuring they reach the right places in the body more effectively.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia Univ New York Morningside NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10907695 on NIH RePORTER |
What this research studies
This research focuses on enhancing the delivery of exosomes, which are tiny particles that can help repair heart and lung injuries. The approach involves modifying these exosomes to ensure they effectively reach damaged tissues, particularly after events like heart attacks or lung injuries. By improving how these exosomes bind to injured blood vessels and are taken up by target cells, the research aims to maximize their therapeutic potential. The study builds on previous findings that stem cells can aid in recovery through indirect mechanisms rather than direct replacement.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients who have experienced acute lung injury or myocardial infarction.
Not a fit: Patients with chronic conditions unrelated to acute lung or heart injuries may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients suffering from acute lung and heart injuries.
How similar studies have performed: Other research has shown promise in using exosomes for therapeutic purposes, indicating a growing interest and potential in this area.
Where this research is happening
New York, United States
- Columbia Univ New York Morningside — New York, United States (Active)
Researchers
- Principal investigator: Cheng, Ke — Columbia Univ New York Morningside
- Study coordinator: Cheng, Ke
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.