Using exosomes to deliver micro RNA for treating resistant lung cancer
Official title: Exosomal Based micro RNA delivery for Resistant Lung Cancer
Funded at Florida Agricultural and Mechanical Univ · NIH-11061353 · Data updated 2026-11-12
This study is testing a new treatment for non-small cell lung cancer that doesn't respond to regular therapies, using tiny particles from immune cells to deliver special molecules that can help fight the cancer and hopefully make patients feel better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Florida Agricultural and Mechanical Univ NIH-funded |
| Lab location | 1 site (Tallahassee, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $148,000 |
| NIH project number | 5R16GM149462-03 |
| Project ID | NIH-11061353 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with non-small cell lung cancer who have developed resistance to current treatments.
✕Less likely to help
Patients with early-stage lung cancer or those who have not yet undergone treatment may not benefit from this research.
What this research studies
This research focuses on developing a novel treatment for non-small cell lung cancer (NSCLC) that has become resistant to standard therapies. The approach involves using exosomes derived from natural killer cells to deliver therapeutic micro RNA that targets specific proteins associated with cancer progression. By analyzing tumor responses in laboratory models, the researchers aim to understand how these exosomes can effectively reduce tumor burden and improve patient outcomes. The study utilizes advanced bioreactor technology to produce these exosomes and assesses their efficacy in killing cancer cells.
Why it matters
Potential benefit: If successful, this research could provide a new, effective treatment option for patients with resistant lung cancer.
How similar studies have gone: Other research has shown promising results using exosomes for cancer treatment, indicating that this approach has potential for success.
Where this research is happening
-
Florida Agricultural and Mechanical Univ
Tallahassee, United States Active
Researchers
- Principal investigator: Sachdeva, Mandip Singh — Florida Agricultural and Mechanical Univ
- Study coordinator: Sachdeva, Mandip Singh
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.