Using exosomes from healthy brain cells to improve memory in older diabetic rats
Official title: Cerebral endothelial cells derived exosomes as a therapy for cognitive impairment in aged diabetic rats
Funded at Henry Ford Health System · NIH-11077210 · Data updated 2026-11-12
This study is looking at how tiny particles from brain cells might help improve thinking and memory in older rats with diabetes, and it hopes to find ways to boost brain health for older people dealing with similar issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Henry Ford Health System NIH-funded |
| Lab location | 1 site (Detroit, United States) |
| Project start | April 1, 2021 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $379,316 |
| NIH project number | 5R01AG068072-05 |
| Project ID | NIH-11077210 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would be older adults suffering from cognitive impairment related to diabetes.
✕Less likely to help
Patients who are not diabetic or do not experience cognitive decline may not benefit from this research.
What this research studies
This research investigates how exosomes, which are tiny particles released by brain cells, can be used to treat cognitive decline in older rats with diabetes. The study aims to understand the role of these exosomes in improving brain function and promoting the growth of new brain cells. By comparing the effects of exosomes from healthy brain cells to those from diabetic rats, the researchers hope to find a way to enhance cognitive abilities and restore brain health in aging populations affected by diabetes.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve memory and cognitive function in older adults with diabetes.
How similar studies have gone: Other research has shown promising results using exosomes for cognitive improvement, suggesting this approach may be effective.
Where this research is happening
-
Henry Ford Health System
Detroit, United States Active
Researchers
- Principal investigator: Zhang, Li — Henry Ford Health System
- Study coordinator: Zhang, Li
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.