Using exosomes from astrocytes to find biomarkers for multiple sclerosis
Astrocyte-specific exosomes as a platform for biomarker discovery in multiple sclerosis
['FUNDING_R21'] · YALE UNIVERSITY · NIH-10645224
This study is looking at tiny particles released by brain cells to see if they can help us find better ways to track how multiple sclerosis changes over time, which could lead to improved care for people living with the condition.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-10645224 on ClinicalTrials.gov |
What this research studies
This research investigates the role of exosomes, tiny vesicles secreted by astrocytes, in identifying biomarkers for multiple sclerosis (MS). By isolating these exosomes from patient plasma, the study aims to understand how their content changes in response to different disease states, such as acute demyelination and disease progression. The researchers will validate the source of these exosomes and analyze their microRNA content to provide insights into MS pathology. This approach could lead to more reliable methods for monitoring disease activity and progression in MS patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with multiple sclerosis, particularly those experiencing acute demyelination or secondary progression of the disease.
Not a fit: Patients with other neurological conditions or those not diagnosed with multiple sclerosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new biomarkers that help in the diagnosis and monitoring of multiple sclerosis.
How similar studies have performed: Other research has shown promise in using exosomes for biomarker discovery in various conditions, suggesting that this approach could be effective for multiple sclerosis as well.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PITT, DAVID — YALE UNIVERSITY
- Study coordinator: PITT, DAVID
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease, Amyotrophic Lateral Sclerosis Motor Neuron Disease, Gehrig's Disease