Using existing drugs to target protein interactions involved in Alzheimer's disease
Repurposing FDA-approved drugs to disrupt tau- and amyloid-associated protein-protein interactions in Alzheimer's disease aggregates
This study is looking at how certain approved medications might help break up harmful protein clumps in the brain that are linked to Alzheimer's disease, with the hope of finding new treatments that could slow down the progression of the condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Central Arkansas Veterans Hlthcare Sys NIH-funded |
| Lab location | 1 site (North Little Rock, United States) |
| Project ID | NIH-10925593 on NIH RePORTER |
What this research studies
This research investigates how FDA-approved drugs can disrupt harmful protein interactions that contribute to Alzheimer's disease. By analyzing protein aggregates in brain tissue, the team identifies specific interactions that are crucial for the disease's progression. They utilize advanced techniques, including machine learning and in-silico screening, to find effective drug candidates that can be tested in laboratory models. The ultimate goal is to find treatments that can reduce protein aggregation and potentially slow down the disease's progression.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at risk of developing it.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively reduce the progression of Alzheimer's disease.
How similar studies have performed: Previous research has shown promise in repurposing existing drugs for neurodegenerative diseases, indicating potential success for this approach.
Where this research is happening
North Little Rock, United States
- Central Arkansas Veterans Hlthcare Sys — North Little Rock, United States (Active)
Researchers
- Principal investigator: Shmookler Reis, Robert Joseph — Central Arkansas Veterans Hlthcare Sys
- Study coordinator: Shmookler Reis, Robert Joseph
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.