Using existing bone treatments to help prevent back pain from disc degeneration in older mice
Repurpose bone therapeutics for intervertebral disc degeneration in aged mice
['FUNDING_R01'] · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · NIH-10901960
This study is looking at ways to use existing bone treatments to help protect the discs in your back from wearing down and to ease the pain that often comes with it, especially for older adults, by testing these ideas on older mice.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10901960 on ClinicalTrials.gov |
What this research studies
This research focuses on intervertebral disc degeneration, a leading cause of low back pain, particularly in older adults. The team aims to repurpose existing bone therapeutics to protect against disc degeneration and alleviate associated pain. By studying the molecular mechanisms involved, they hope to understand how these treatments can be effective in reducing disc loss and improving mobility. The research will involve aged mice to model the effects of these therapeutics on disc health and pain management.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing low back pain due to intervertebral disc degeneration.
Not a fit: Patients who are younger or do not have issues related to intervertebral disc degeneration may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or reduce back pain caused by disc degeneration in older adults.
How similar studies have performed: Previous research has shown promise in repurposing existing therapeutics for similar conditions, indicating potential for success in this approach.
Where this research is happening
NEW YORK, UNITED STATES
- ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HOLGUIN, NILSSON — ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Study coordinator: HOLGUIN, NILSSON
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.