Using existing antibiotics to fight resistant bacterial infections
Repurposing Gram-positive Antibiotics for Gram-Negative Bacteria using Antibiotic Adjuvants
This study is looking for ways to help people with tough infections caused by a bacteria called Acinetobacter baumannii, which is hard to treat because it's resistant to many antibiotics, by testing new helpers that can make existing antibiotics work better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Notre Dame NIH-funded |
| Lab location | 1 site (Notre Dame, United States) |
| Project ID | NIH-10884357 on NIH RePORTER |
What this research studies
This research focuses on addressing the challenge of multi-drug resistant Acinetobacter baumannii infections, which are increasingly difficult to treat due to antibiotic resistance. The team is investigating the use of antibiotic adjuvants to enhance the effectiveness of macrolide antibiotics, such as clarithromycin, against these resistant bacteria. By identifying small molecules that can lower the required doses of antibiotics, the research aims to provide new treatment options for patients suffering from these infections. The approach involves laboratory testing to determine how these adjuvants can improve antibiotic efficacy.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients suffering from infections caused by multi-drug resistant Acinetobacter baumannii.
Not a fit: Patients with infections caused by bacteria other than Acinetobacter baumannii may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with difficult-to-treat bacterial infections.
How similar studies have performed: Other research has shown promise in using antibiotic adjuvants to enhance the effectiveness of existing antibiotics, suggesting potential for success in this approach.
Where this research is happening
Notre Dame, United States
- University of Notre Dame — Notre Dame, United States (Active)
Researchers
- Principal investigator: Melander, Christian Corey — University of Notre Dame
- Study coordinator: Melander, Christian Corey
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.