Using engineered particles to improve bone healing in the mouth
Biomimetic Apoptotic Particles for Macrophage-driven Oral Bone Regeneration
This study is looking at how tiny particles that act like dying cells can help your mouth heal better after dental work by encouraging your immune cells to promote bone healing, especially for those who might have trouble healing normally.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-11253941 on NIH RePORTER |
What this research studies
This research investigates how engineered particles that mimic dying cells can enhance the healing process of bone in the oral cavity, particularly after dental procedures. It focuses on the role of macrophages, a type of immune cell, in clearing these particles and promoting regeneration through the secretion of healing factors. By understanding how these cells respond to the particles, the research aims to develop new therapies that can improve bone quality and healing in patients with compromised healing abilities.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who have experienced delayed wound healing or have conditions affecting their bone repair capacity.
Not a fit: Patients who do not have issues with bone healing or are under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved healing and success rates for dental implants in patients with poor bone regeneration.
How similar studies have performed: Previous research has shown promise in using similar bioengineered approaches to enhance tissue regeneration, indicating potential for success in this area.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Kannan, Rahasudha — University of Michigan at Ann Arbor
- Study coordinator: Kannan, Rahasudha
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.