Using engineered mice to understand lung cancer therapy
Epigenetically Engineered Mouse Model for Lung Cancer Therapy
['FUNDING_R01'] · BAYLOR COLLEGE OF MEDICINE · NIH-10881763
This study is looking at how changes in DNA can affect lung cancer growth and treatment, using a special mouse model to learn more about the p16 gene and its relationship with other genetic changes, which could help find better ways to treat lung cancer.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BAYLOR COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-10881763 on ClinicalTrials.gov |
What this research studies
This research focuses on the role of DNA methylation in the development and progression of lung cancer. By creating a specialized mouse model, the researchers aim to investigate how specific epigenetic changes, particularly in the p16 gene, contribute to tumor formation and response to treatment. The study will explore the interactions between these epigenetic modifications and genetic mutations, such as those in the K-RAS gene, to better understand lung cancer biology. This approach could lead to more effective therapies by identifying critical pathways involved in cancer development.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with lung cancer, particularly those with adenocarcinoma or related genetic mutations.
Not a fit: Patients with non-lung cancers or those without specific epigenetic alterations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for lung cancer by targeting epigenetic changes.
How similar studies have performed: Previous research has shown promise in using animal models to study cancer mechanisms, indicating that this approach could yield valuable insights.
Where this research is happening
HOUSTON, UNITED STATES
- BAYLOR COLLEGE OF MEDICINE — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHEN, LANLAN — BAYLOR COLLEGE OF MEDICINE
- Study coordinator: SHEN, LANLAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.