Using engineered heart cells to repair damaged hearts
Nanowired hypoimmunogenic hPSC cardiac organoids for heart repair
This study is exploring a new way to help heal heart damage from heart attacks by creating tiny heart-like structures from your own cells, which could lead to better treatments that work well with your body.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Clemson University NIH-funded |
| Lab location | 1 site (Clemson, United States) |
| Project ID | NIH-11099948 on NIH RePORTER |
What this research studies
This research focuses on developing innovative cardiac organoids made from human pluripotent stem cell-derived heart cells to treat heart damage caused by conditions like heart attacks. The approach involves creating these organoids with special nanowires to enhance their integration and function when implanted in the heart. By modifying the cells to reduce immune rejection, the goal is to improve the success of heart repair therapies. Patients may benefit from a more effective treatment option for heart repair that utilizes their own cells.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have suffered from myocardial infarction or other forms of heart damage.
Not a fit: Patients with non-cardiac conditions or those who do not have significant heart damage may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a groundbreaking method for repairing damaged heart tissue, potentially improving recovery outcomes for heart attack patients.
How similar studies have performed: Previous studies have shown promise in using stem cell-derived therapies for heart repair, indicating a potential for success with this novel approach.
Where this research is happening
Clemson, United States
- Clemson University — Clemson, United States (Active)
Researchers
- Principal investigator: Mei, Ying — Clemson University
- Study coordinator: Mei, Ying
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.