Using engineered extracellular vesicles and growth factors to improve bone healing
Official title: Dual Delivery of Engineered EVs and Growth Factor for Bone Regeneration
Funded at University of Illinois at Chicago · NIH-11076831 · Data updated 2026-11-12
This study is looking at a new way to help heal bone injuries in people with type 2 diabetes by using special tiny particles and a growth factor to boost bone repair and reduce inflammation, making recovery easier and more effective.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project start | June 16, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $439,429 |
| NIH project number | 5R01DE033167-03 |
| Project ID | NIH-11076831 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with type 2 diabetes who are experiencing challenges with bone healing.
✕Less likely to help
Patients without type 2 diabetes or those not facing issues related to bone healing may not benefit from this research.
What this research studies
This research investigates how engineered extracellular vesicles (EVs) combined with a growth factor can enhance bone regeneration, particularly in patients with type 2 diabetes. The study focuses on the role of the immune system in bone healing and aims to address the challenges posed by inflammation in these patients. By utilizing a dual delivery system that combines MSC-derived EVs with a well-known bone growth factor, the research seeks to improve treatment outcomes for bone injuries. Patients may benefit from a novel approach that targets both bone repair and inflammation simultaneously.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for bone healing in patients with type 2 diabetes.
How similar studies have gone: Other research has shown promise in using engineered EVs for tissue repair, suggesting that this approach could be effective.
Where this research is happening
-
University of Illinois at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Kang, Miya — University of Illinois at Chicago
- Study coordinator: Kang, Miya
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.