Using engineered cells to treat muscle fibrosis
Official title: Engineering Mesenchymal Stromal Cells to treat Muscle Fibrosis
Funded at Colorado State University · NIH-10917353 · Data updated 2026-11-12
This study is looking at a new way to help muscle healing by using special gels to boost the effectiveness of certain cells that can break down scar tissue, which could help people with muscle fibrosis feel better and recover faster.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Colorado State University NIH-funded |
| Lab location | 1 site (Fort Collins, United States) |
| Project start | September 1, 2023 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $236,501 |
| NIH project number | 5R00AR079561-04 |
| Project ID | NIH-10917353 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would include individuals suffering from muscle fibrosis or related muscular dystrophies.
✕Less likely to help
Patients with non-fibrotic muscle conditions or those who do not have muscle-related issues may not benefit from this research.
What this research studies
This research focuses on enhancing the ability of mesenchymal stromal cells (MSCs) to treat muscle fibrosis by encapsulating them in specially designed gel coatings. These coatings provide specific biochemical and biophysical signals that help MSCs produce enzymes capable of breaking down excess collagen, which is a key factor in fibrosis. The study aims to understand how these engineered gels can activate MSCs to reduce collagen buildup in muscle tissue, potentially leading to improved muscle regeneration. Patients may benefit from this innovative approach if it proves effective in clinical settings.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly improve muscle healing and function in patients with fibrosis.
How similar studies have gone: Previous research has shown promise in using MSCs for tissue regeneration, suggesting that this approach could build on existing knowledge and potentially lead to successful outcomes.
Where this research is happening
-
Colorado State University
Fort Collins, United States Active
Researchers
- Principal investigator: Wong, Sing-Wan — Colorado State University
- Study coordinator: Wong, Sing-Wan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.