Using engineered brain cell vesicles to improve recovery after stroke
Engineering Extracellular Vesicles of Human Brain Organoids for Stroke Therapy
['FUNDING_R01'] · FLORIDA STATE UNIVERSITY · NIH-11041021
This study is exploring how tiny particles made from human brain cells can help stroke patients recover by protecting brain cells and promoting healing, with the hope of creating new treatments that improve recovery after a stroke.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | FLORIDA STATE UNIVERSITY (nih funded) |
| Locations | 1 site (TALLAHASSEE, UNITED STATES) |
| Trial ID | NIH-11041021 on ClinicalTrials.gov |
What this research studies
This research focuses on developing extracellular vesicles (EVs) from human brain organoids to enhance recovery in stroke patients. By utilizing brain organoids derived from human stem cells, the study aims to understand how these EVs can protect neurons and promote healing in damaged brain tissue. The approach involves engineering these vesicles to carry specific microRNAs that target ischemic areas in the brain, potentially improving functional recovery. Patients may benefit from innovative therapies derived from this research that could lead to better outcomes after a stroke.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults who have experienced a stroke and are seeking new therapeutic options for recovery.
Not a fit: Patients who have not suffered a stroke or have other unrelated neurological conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a novel treatment option that significantly improves recovery for stroke patients.
How similar studies have performed: While the use of extracellular vesicles in therapy is a growing field, this specific approach using brain organoids is relatively novel and has not been extensively tested.
Where this research is happening
TALLAHASSEE, UNITED STATES
- FLORIDA STATE UNIVERSITY — TALLAHASSEE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LI, YAN — FLORIDA STATE UNIVERSITY
- Study coordinator: LI, YAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.