Using electrical pulses and immunotherapy to treat pancreatic cancer
Combining Irreversible Electroporation with Immunotherapy for the Systemic Treatment of Pancreatic Cancer
This study is exploring a new way to treat pancreatic cancer by using electrical pulses to help the immune system better fight the tumors, and it's aimed at improving outcomes for patients facing this tough diagnosis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11008920 on NIH RePORTER |
What this research studies
This research investigates a novel approach to treating pancreatic cancer by combining irreversible electroporation (IRE) with immunotherapy. IRE is a technique that uses electrical pulses to create openings in tumor cells, allowing for better delivery of immune-boosting agents. The goal is to enhance the body's immune response against pancreatic tumors, potentially reducing the chances of cancer recurrence and improving overall survival. The research will involve preclinical models to compare the effectiveness of IRE against traditional radiation therapy.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with locally advanced pancreatic cancer who are not eligible for surgical removal of their tumors.
Not a fit: Patients with early-stage pancreatic cancer or those whose tumors are completely resectable may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for pancreatic cancer, potentially improving survival rates and quality of life for patients.
How similar studies have performed: Previous studies have shown promising results using similar approaches, indicating potential for success in this novel combination therapy.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: White, Rebekah — University of California, San Diego
- Study coordinator: White, Rebekah
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.