Using electric pulses to improve bladder reconstruction with patients' own tissue
Intrasurgical tissue engineering of autologous grafts using irreversible electroporation for bladder reconstruction
This study is exploring a new way to improve bladder reconstruction by using a patient's own intestine, and it aims to help the bladder heal better by using a special technique to remove certain cells that could get in the way; it's being tested in rats to see how well it works.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Massachusetts Amherst NIH-funded |
| Lab location | 1 site (Hadley, United States) |
| Project ID | NIH-10883586 on NIH RePORTER |
What this research studies
This research focuses on enhancing bladder reconstruction by using a patient's own intestinal tissue as a graft. The approach involves applying irreversible electroporation (IRE) to selectively eliminate intestinal cells from the graft, which can hinder the regeneration of bladder tissue. By doing so, the goal is to promote the growth of bladder-specific cells, improving the functionality of the reconstructed bladder. The study will utilize a rat model to test the effectiveness of this innovative technique.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients requiring bladder reconstruction due to conditions like neurogenic bladder, congenital disorders, or complications from bladder cancer treatment.
Not a fit: Patients who do not require bladder reconstruction or have other unrelated urinary issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective bladder reconstructions, reducing complications and improving urinary function for patients.
How similar studies have performed: While the use of electroporation in tissue engineering is a novel approach, preliminary data suggests promising results in similar applications.
Where this research is happening
Hadley, United States
- University of Massachusetts Amherst — Hadley, United States (Active)
Researchers
- Principal investigator: Srimathveeravalli, Govindarajan — University of Massachusetts Amherst
- Study coordinator: Srimathveeravalli, Govindarajan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.