Using drugs to improve lysosomal function in Alzheimer's disease and related dementias
Pharmacologic Lysosomal Flux Activators to Ameliorate Alzheimer's Disease and Related Dementias
This study is looking at how boosting a part of your cells called lysosomes might help ease the symptoms of Alzheimer's and similar conditions, by finding new drugs that can safely help clear out harmful substances in the brain.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scripps Research Institute, the NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10883957 on NIH RePORTER |
What this research studies
This research investigates how activating lysosomal function can help alleviate the symptoms of Alzheimer's disease and related dementias. By screening a vast library of small molecules, the researchers aim to identify new drugs that can enhance lysosomal activity without the side effects associated with current treatments. The study will explore various mechanisms of action for these compounds, focusing on their ability to clear harmful substances from cells. Patients may benefit from improved treatments that target the underlying causes of their conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related dementias.
Not a fit: Patients with other forms of dementia not related to Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly improve the quality of life for patients with Alzheimer's disease and related dementias.
How similar studies have performed: Previous research has shown promise in using lysosomal activators for neurodegenerative diseases, suggesting that this approach could be effective.
Where this research is happening
La Jolla, United States
- Scripps Research Institute, the — La Jolla, United States (Active)
Researchers
- Principal investigator: Kelly, Jeffery W — Scripps Research Institute, the
- Study coordinator: Kelly, Jeffery W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.