Using dronabinol to help reduce chronic pain and inflammation in sickle cell disease
Dronabinol for the reduction of chronic pain and inflammation in people with sickle cell disease
['FUNDING_OTHER'] · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · NIH-11141011
This study is looking at how a medication called dronabinol, which contains THC, can help reduce chronic pain and inflammation in adults with sickle cell disease, and it will compare its effects to a placebo over eight weeks to see if it improves pain, quality of life, and safety for those who take it.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11141011 on ClinicalTrials.gov |
What this research studies
This research investigates the effects of dronabinol, a THC-containing medication, on chronic pain and inflammation in adults with sickle cell disease (SCD). The study will involve a placebo-controlled, double-masked design over eight weeks, where participants will receive either dronabinol or a placebo. The research aims to assess improvements in pain levels, quality of life, and inflammation markers, while also evaluating the safety and tolerability of the treatment. This approach seeks to provide evidence-based guidance for patients and healthcare providers regarding the use of cannabinoids for pain management in SCD.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who suffer from chronic pain associated with sickle cell disease.
Not a fit: Patients who do not have sickle cell disease or those who are not experiencing chronic pain may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a new, effective treatment option for managing chronic pain in patients with sickle cell disease.
How similar studies have performed: While cannabinoids have shown promise in treating chronic pain in other conditions, this specific approach in sickle cell disease is novel and has not been extensively tested.
Where this research is happening
NEW YORK, UNITED STATES
- ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CURTIS, SUSANNA — ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Study coordinator: CURTIS, SUSANNA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.