Using DNA nanostructures to improve imaging of small proteins
DNA Nanostructures for High-Throughput Cryo-EM Studies of Small Macromolecules
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-11041109
This study is exploring a new way to take clearer pictures of tiny proteins using advanced imaging techniques, which could help scientists design better drugs and treatments for patients.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-11041109 on ClinicalTrials.gov |
What this research studies
This research focuses on enhancing the visualization of small macromolecules, particularly proteins, using advanced cryo-electron microscopy (cryo-EM) techniques. By employing DNA nanostructures as molecular goniometers, the study aims to precisely orient these small proteins for better imaging without the need for large sample quantities. This innovative approach allows for the detailed observation of protein structures at near-native conditions, which is crucial for understanding their biological functions. Patients may benefit from improved drug design and therapeutic strategies as a result of better structural insights into these proteins.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with conditions related to small macromolecules, such as certain cancers or genetic disorders involving protein dysfunction.
Not a fit: Patients with conditions unrelated to small macromolecules or those who do not have a specific protein target of interest may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to significant advancements in drug development and personalized medicine by providing detailed structural information about small proteins.
How similar studies have performed: Other research has shown success with similar cryo-EM techniques, but the use of DNA nanostructures for this specific application is relatively novel.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DOUGLAS, SHAWN M — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: DOUGLAS, SHAWN M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.