Using digoxin to treat nonalcoholic steatohepatitis (NASH)
Official title: Oral digoxin for the treatment of NASH
Funded at Yale University · NIH-11052494 · Data updated 2026-11-12
This study is looking at how digoxin, a common and affordable medication, might help people with nonalcoholic steatohepatitis (NASH) by reducing liver inflammation and damage, with the hope of finding a better treatment for this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | March 15, 2024 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $548,339 |
| NIH project number | 5R01DK134624-02 |
| Project ID | NIH-11052494 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with nonalcoholic steatohepatitis (NASH).
✕Less likely to help
Patients with liver conditions unrelated to NASH or those who are not eligible for digoxin treatment may not benefit from this research.
What this research studies
This research investigates the use of digoxin, a generic medication, to treat nonalcoholic steatohepatitis (NASH), a liver condition that can lead to serious health issues. The study aims to explore how digoxin can reduce inflammation and liver damage by targeting specific immune responses. By examining its effects on liver health, the research seeks to provide an affordable treatment option for a condition that currently lacks effective therapies. Patients may be monitored for changes in liver function and overall health during the treatment period.
Why it matters
Potential benefit: If successful, this research could provide a cost-effective treatment option for patients suffering from NASH.
How similar studies have gone: Previous studies have shown promising results for the use of digoxin in liver conditions, indicating potential for success in this novel application.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Banini, Bubu Ama — Yale University
- Study coordinator: Banini, Bubu Ama
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.