Using digital models to personalize brain stimulation for depression treatment
Scalable Biomarkers and Generative Digital Twins for Personalized Neurostimulation in Depression
This study is looking at how we can make depression treatments better by using special brain models to personalize noninvasive therapies like rTMS, so that each person gets a treatment that works best for them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10906262 on NIH RePORTER |
What this research studies
This research investigates how to improve treatment for clinical depression by using personalized digital models of patients' brains. It focuses on noninvasive neurostimulation therapies, such as repetitive Transcranial Magnetic Stimulation (rTMS), which can stimulate the brain to alleviate symptoms of depression. The goal is to tailor these treatments based on individual neurophysiology, potentially leading to more effective and lasting outcomes for patients. By understanding why some patients respond well to rTMS while others do not, the research aims to create a more reliable and personalized approach to depression treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with clinical depression, especially those who have experienced treatment-resistant depression.
Not a fit: Patients with mild depressive symptoms or those who have not been diagnosed with clinical depression may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide patients with more effective and personalized treatment options for depression, particularly for those who have not responded to traditional therapies.
How similar studies have performed: Previous research has shown promise in using personalized approaches to neurostimulation, suggesting that this innovative method could lead to significant advancements in depression treatment.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Grosenick, Logan — Weill Medical Coll of Cornell Univ
- Study coordinator: Grosenick, Logan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.