Using dietary ketone supplements to reduce health risks from high salt intake in older adults
Official title: Dietary Ketone Supplementation as a Novel Strategy to Attenuate the Adverse Vascular and Renal Consequences of High Dietary Salt in Older Adults
Funded at Trustees of Indiana University · NIH-10896634 · Data updated 2026-11-12
This study is looking at whether taking ketone supplements can help older adults who eat a lot of salt protect their heart and kidneys from any harm caused by the extra salt.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Trustees of Indiana University NIH-funded |
| Lab location | 1 site (Bloomington, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $243,948 |
| NIH project number | 1R21AG087524-01A1 |
| Project ID | NIH-10896634 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults who regularly consume high amounts of dietary salt and are at risk for hypertension and chronic kidney disease.
✕Less likely to help
Patients who do not consume high levels of dietary salt or those with pre-existing severe cardiovascular or renal conditions may not benefit from this research.
What this research studies
This research investigates the effects of dietary ketone supplementation on older adults who consume high levels of salt. It aims to determine whether these supplements can help mitigate the negative impacts of excess salt on heart and kidney health. The study will involve administering oral ketone supplements to participants and monitoring their cardiovascular and renal functions. By focusing on a population that struggles with high salt intake, the research seeks to provide a practical solution to a common dietary challenge.
Why it matters
Potential benefit: If successful, this research could lead to new dietary strategies that improve heart and kidney health for older adults consuming high salt diets.
How similar studies have gone: Previous research has shown promising results with ketone supplementation in animal models, suggesting potential for success in human applications.
Where this research is happening
-
Trustees of Indiana University
Bloomington, United States Active
Researchers
- Principal investigator: Robinson, Austin Tyler — Trustees of Indiana University
- Study coordinator: Robinson, Austin Tyler
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.