Using dietary ketone supplements to reduce health risks from high salt intake in older adults

Dietary Ketone Supplementation as a Novel Strategy to Attenuate the Adverse Vascular and Renal Consequences of High Dietary Salt in Older Adults

NIH-funded research Trustees of Indiana University · NIH-10896634

This study is looking at whether taking ketone supplements can help older adults who eat a lot of salt protect their heart and kidneys from any harm caused by the extra salt.

Quick facts

Grant typeR21 grant
Study typeNIH-funded research
Funding institutionTrustees of Indiana University NIH-funded
Lab location1 site (Bloomington, United States)
Project IDNIH-10896634 on NIH RePORTER

What this research studies

This research investigates the effects of dietary ketone supplementation on older adults who consume high levels of salt. It aims to determine whether these supplements can help mitigate the negative impacts of excess salt on heart and kidney health. The study will involve administering oral ketone supplements to participants and monitoring their cardiovascular and renal functions. By focusing on a population that struggles with high salt intake, the research seeks to provide a practical solution to a common dietary challenge.

Who could benefit from this research

Good fit: Ideal candidates for this research are older adults who regularly consume high amounts of dietary salt and are at risk for hypertension and chronic kidney disease.

Not a fit: Patients who do not consume high levels of dietary salt or those with pre-existing severe cardiovascular or renal conditions may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to new dietary strategies that improve heart and kidney health for older adults consuming high salt diets.

How similar studies have performed: Previous research has shown promising results with ketone supplementation in animal models, suggesting potential for success in human applications.

Where this research is happening

Bloomington, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.