Using dexamethasone to treat eye injuries caused by chemical agents.
Official title: Dexamethasone as an Effective Therapy for Ocular Injuries by Vesicating Agents.
Funded at University of Colorado Denver · NIH-10695182 · Data updated 2026-11-12
This study is looking at how well dexamethasone, a common anti-inflammatory medicine, can help treat eye injuries caused by strong chemicals, and it's being tested in animals to find the best way to help people who might be affected.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | August 1, 2020 |
| Project end | July 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $708,058 |
| NIH project number | 5U01EY030405-04 |
| Project ID | NIH-10695182 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who have experienced ocular injuries due to exposure to chemical agents.
✕Less likely to help
Patients with ocular injuries not related to chemical exposure may not benefit from this research.
What this research studies
This research investigates the effectiveness of dexamethasone, a well-known anti-inflammatory medication, in treating ocular injuries caused by potent chemical agents like sulfur mustard, nitrogen mustard, and lewisite. The study utilizes animal models to understand the mechanisms of these injuries and the therapeutic potential of dexamethasone. By identifying key inflammatory mediators involved in the injury process, the research aims to establish a reliable treatment protocol that could be applied in clinical settings for affected patients.
Why it matters
Potential benefit: If successful, this research could provide a new treatment option for patients suffering from severe eye injuries caused by chemical exposure.
How similar studies have gone: Previous research has shown that dexamethasone is effective in treating various inflammatory conditions, suggesting a promising potential for this novel application.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Agarwal, Rajesh — University of Colorado Denver
- Study coordinator: Agarwal, Rajesh
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.