Using deferiprone to enhance cognitive recovery after subarachnoid hemorrhage
Official title: The Use of Deferiprone to Improve Subarachnoid Hemorrhage Cognitive Outcome: U-DISCO
Funded at Duke University · NIH-11303175 · Data updated 2026-11-12
This study is looking at how a medication called deferiprone, which helps lower iron levels in the brain, might improve memory and thinking skills in people who have recovered from a brain bleed called aneurysmal subarachnoid hemorrhage.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | June 15, 2022 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $1,081,941 |
| NIH project number | 3R01AG068848-05S1 |
| Project ID | NIH-11303175 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have recently survived an aneurysmal subarachnoid hemorrhage and are experiencing cognitive deficits.
✕Less likely to help
Patients who have not experienced aSAH or those with pre-existing severe cognitive impairments unrelated to aSAH may not benefit from this research.
What this research studies
This research investigates the effects of deferiprone, a medication that reduces iron levels in the brain, on cognitive outcomes in patients who have survived aneurysmal subarachnoid hemorrhage (aSAH). The study aims to understand how reducing iron accumulation can improve memory and cognitive function, which are often impaired after such hemorrhages. By analyzing data from both animal models and human subjects, the researchers hope to establish a clear link between iron toxicity and cognitive decline, ultimately leading to better treatment options for affected patients.
Why it matters
Potential benefit: If successful, this research could lead to improved cognitive recovery and quality of life for patients who have survived aSAH.
How similar studies have gone: Previous studies have shown promising results in using deferiprone to mitigate iron-related neuronal damage, suggesting potential for success in this novel application.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Hasan, David M. — Duke University
- Study coordinator: Hasan, David M.
Related research
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Cognitive screening after an aneurysmal brain bleed
Using patient questionnaires to find thinking and memory problems in people recovering from aneurysmal subarachnoid hemorrhage.
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This project is creating a blood test to spot which people who had a brain aneurysm bleed are likely to develop delayed brain injury in the days after the bleed.
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Biomarkers to Fine-Tune Intrathecal Nicardipine for Brain Bleeding-Related Stroke
Researchers are testing biomarkers to personalize intrathecal nicardipine treatment for patients after subarachnoid hemorrhage to prevent brain damage.
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Adropin as a shield for the brain after a brain hemorrhage
A potential treatment with adropin is being studied to protect brain cells after a subarachnoid hemorrhage and reduce stroke-like damage.
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Manganese-based compound as a potential therapy for subarachnoid hemorrhage
A new manganese porphyrin-based drug is being explored as a possible treatment to reduce brain injury after a subarachnoid hemorrhage.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.