Using deep RNA sequencing to improve sepsis diagnosis and treatment
Improving Sepsis Care with Deep RNA Sequencing Data
This study is looking at the blood of people with sepsis to find out what germs are making them sick and how to improve their treatment, so we can help patients recover better and faster.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rhode Island Hospital NIH-funded |
| Lab location | 1 site (Providence, United States) |
| Project ID | NIH-10863920 on NIH RePORTER |
What this research studies
This research aims to enhance the understanding and treatment of sepsis, a critical condition responsible for many deaths worldwide. By analyzing deep RNA sequencing data from the blood of sepsis patients, the study seeks to identify the pathogens causing the illness, predict patient outcomes, and discover new therapeutic targets. The approach includes advanced computational methods to assess microbial populations and RNA biology, focusing on RNA splicing and its potential as a biomarker for sepsis. This innovative methodology could lead to better diagnostic tools and treatment strategies for affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with sepsis who are receiving treatment in intensive care units.
Not a fit: Patients with conditions unrelated to sepsis or those not currently hospitalized may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnosis and treatment options for sepsis, potentially saving lives.
How similar studies have performed: Other research has shown promise in using RNA sequencing for diagnosing infectious diseases, indicating potential success for this novel approach.
Where this research is happening
Providence, United States
- Rhode Island Hospital — Providence, United States (Active)
Researchers
- Principal investigator: Monaghan, Sean Farrell — Rhode Island Hospital
- Study coordinator: Monaghan, Sean Farrell
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.