Using deep brain stimulation to enhance muscle control after a stroke
Deep brain stimulation of the motor thalamus to improve cortico-spinal control of muscles after stroke
This study is exploring how deep brain stimulation can help stroke survivors regain better muscle control by targeting specific areas in the brain, with the hope of offering a new treatment option alongside regular therapy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10999434 on NIH RePORTER |
What this research studies
This research investigates the use of deep brain stimulation (DBS) targeting the motor thalamus to improve muscle control in individuals who have experienced a stroke. The approach involves identifying the optimal stimulation targets and parameters through studies in monkeys, with the goal of enhancing motor output by increasing the excitability of cortical motoneurons. If successful, this method could provide a new therapeutic option for stroke survivors beyond traditional physical therapy.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have suffered a stroke and experience moderate to severe motor deficits.
Not a fit: Patients who have not experienced a stroke or have mild motor impairments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved motor function and quality of life for stroke survivors.
How similar studies have performed: Previous research has shown promise in using deep brain stimulation for various neurological conditions, suggesting potential success for this novel application.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Pirondini, Elvira — University of Pittsburgh at Pittsburgh
- Study coordinator: Pirondini, Elvira
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.