Using decorin mimetics to treat corneal scarring and blood vessel growth in the eye
Official title: Decorin mimetics for treating corneal scarring and neovascularization
Funded at University of Houston · NIH-11050569 · Data updated 2026-11-12
This study is looking at a new way to help people with corneal injuries by using special treatments that could stop scarring and unwanted blood vessel growth, which can affect vision.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | May 1, 2025 |
| Project end | April 30, 2030 |
| Funding year | 2025 |
| Award (this year) | $394,285 |
| NIH project number | 1R01EY036014-01A1 |
| Project ID | NIH-11050569 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would include individuals with corneal injuries or conditions leading to scarring and abnormal blood vessel growth in the eye.
✕Less likely to help
Patients with stable corneal conditions that do not involve scarring or neovascularization may not benefit from this research.
What this research studies
This research investigates the use of decorin mimetics to prevent corneal scarring and neovascularization, which can lead to vision loss. The approach focuses on how decorin interacts with growth factors and cell receptors to regulate healing processes in the cornea. By inhibiting specific signaling pathways that promote scarring and abnormal blood vessel growth, this research aims to develop alternative treatments for patients suffering from corneal injuries. The study will involve laboratory experiments and potentially clinical trials to assess the effectiveness of these treatments.
Why it matters
Potential benefit: If successful, this research could provide new treatment options that prevent vision loss due to corneal scarring and neovascularization.
How similar studies have gone: Previous research has shown promise in using decorin and its mimetics for similar therapeutic applications, indicating potential for success in this area.
Where this research is happening
-
University of Houston
Houston, United States Active
Researchers
- Principal investigator: Ferreira, Tarsis G — University of Houston
- Study coordinator: Ferreira, Tarsis G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.