Using data science to improve diagnosis and management of MIS-C in children

Who could benefit from this research

What this research studies

This research investigates the multisystem inflammatory syndrome in children (MIS-C) that has emerged during the SARS-CoV-2 pandemic, particularly its similarities to Kawasaki disease. The study aims to develop machine-learning models to enhance the diagnosis and management of MIS-C by leveraging existing predictive tools for Kawasaki disease. It will involve systematic analysis of clinical features and outcomes, followed by validation of these models in a clinical decision support system to assist healthcare providers in making informed decisions for pediatric patients. The research will focus on children presenting with symptoms indicative of either MIS-C or Kawasaki disease.

Why it matters

Where this research is happening

• Johns Hopkins University
  Baltimore, United States Active

Researchers

• Principal investigator: Barnes, Benjamin — Johns Hopkins University
• Study coordinator: Barnes, Benjamin

Related research

Other NIH-funded projects on the same topics.

• Identifying and managing a serious inflammatory syndrome in children linked to COVID-19.

  This study is looking at a condition called Multisystem Inflammatory Syndrome in Children (MIS-C), which has come up during the COVID-19 pandemic, and aims to create helpful tools for doctors to better diagnose and treat kids with MIS-C or Kawasaki disease by using data from past cases.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-10847802

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  NIH research University of Texas Hlth Science Center · San Antonio, United States · NIH-11617103

• Alzheimer’s-related dementia after COVID-19: how SARS-CoV-2 affects the brain and potential drug repurposing

  This research looks at how COVID-19 may contribute to dementia by studying brain inflammation, blood vessel injury, and virus-host interactions, with the goal of finding existing drugs that could help.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-11457086

• IL-22’s role in SARS-CoV-2 infection and tissue protection

  A short study to understand how the cytokine IL-22 might help protect tissues during and after COVID-19 infection, especially in people with complications related to acute graft-versus-host disease.

  NIH research University of Oklahoma Hlth Sciences Ctr · Oklahoma City, United States · NIH-11451891

• Maternal SARS-CoV-2 infection and its effects on placenta and child development

  This grant studies how COVID-19 infection during pregnancy might change the placenta and influence a child’s brain development, especially in kids who may be at higher genetic risk for ADHD/ASD.

  NIH research Lieber Institute, INC. · Baltimore, United States · NIH-11402254

• How COVID-19 and genetics influence memory and dementia risk in older adults

  This project studies how getting COVID-19 interacts with people’s genetic makeup to affect the likelihood of cognitive decline and Alzheimer’s disease in older adults from diverse backgrounds.

  NIH research University of Texas Hlth Science Center · San Antonio, United States · NIH-11401787

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.