Using data science to improve alcohol-related gut and brain health in people with HIV
Data Science Core: Interventions to improve alcohol-related comorbidities along the gut-brain axis in persons with HIV infection
This project uses data and AI to find better ways to treat alcohol-related gut and brain problems in people living with HIV.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-11163400 on NIH RePORTER |
What this research studies
If you have HIV and drink heavily, this project will combine medical records, gut microbiome tests, brain scans, and other biological data to look for patterns that link drinking with gut and brain problems. A central data science team will clean and combine the data, run statistical and machine-learning analyses, and help shape two intervention efforts aimed at reducing harm. The team will build prediction tools and personalized recommendations to suggest which treatments might work best for different people. Data privacy and secure data sharing will be maintained while findings are shared with clinicians and patients.
Who could benefit from this research
Good fit: Ideal candidates are adults living with HIV who currently drink heavily or have alcohol-related gut or cognitive symptoms and are willing to provide biological samples and clinical data.
Not a fit: People without HIV, those who do not drink heavily, or those unwilling to share medical data or samples are unlikely to benefit from this specific work.
Why it matters
Potential benefit: If successful, this work could lead to personalized tools and treatments that reduce gut inflammation and brain-related problems caused by heavy drinking in people with HIV.
How similar studies have performed: Prior studies have linked alcohol, gut microbes, and brain changes in HIV, but combining multi-omics, neuroimaging, and AI to produce personalized recommendations is relatively new.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Li, Zhigang — University of Florida
- Study coordinator: Li, Zhigang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.