Using data from multiple sources to improve understanding of chronic disease treatments
Generating Reproducible Real-World Evidence with Multi-Source Data to Capture Unstructured Clinical Endpoints for Chronic Diseases
This study is looking at how well different treatments work for chronic diseases by using real patient health records, so we can better understand their long-term effects for all kinds of people.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard Medical School NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10913529 on NIH RePORTER |
What this research studies
This research aims to enhance the understanding of chronic disease treatments by utilizing electronic health record data to capture long-term treatment responses in diverse patient populations. It focuses on generating real-world evidence that complements traditional clinical trial data, addressing the limitations of randomized clinical trials, such as their generalizability and follow-up duration. By developing methods to extract and analyze unstructured clinical information, the project seeks to provide a more comprehensive view of treatment efficacy and safety over time.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with chronic diseases who are receiving disease-modifying treatments and have their health data recorded in electronic health records.
Not a fit: Patients with acute conditions or those not receiving disease-modifying treatments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved monitoring and understanding of chronic disease treatments, ultimately enhancing patient care and outcomes.
How similar studies have performed: Other research has shown success in using electronic health records to generate real-world evidence, indicating that this approach has potential for meaningful contributions to chronic disease management.
Where this research is happening
Boston, United States
- Harvard Medical School — Boston, United States (Active)
Researchers
- Principal investigator: Bourgeois, Florence — Harvard Medical School
- Study coordinator: Bourgeois, Florence
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.