Using cruciferous vegetables to help prevent bladder cancer from coming back
Official title: A scalable cruciferous vegetable intervention to reduce bladder cancer recurrence and progression
Funded at Roswell Park Cancer Institute Corp · NIH-11023489 · Data updated 2026-11-12
This study is looking at whether eating more cruciferous vegetables, like broccoli and kale, can help people with non-muscle invasive bladder cancer lower their chances of the cancer coming back or getting worse, and it’s designed for patients who want to try a natural way to support their health through diet.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Roswell Park Cancer Institute Corp NIH-funded |
| Lab location | 1 site (Buffalo, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $717,150 |
| NIH project number | 1R01CA296175-01 |
| Project ID | NIH-11023489 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with non-muscle invasive bladder cancer who are at risk of recurrence.
✕Less likely to help
Patients with muscle-invasive bladder cancer or those who have already undergone extensive treatment may not benefit from this dietary intervention.
What this research studies
This research investigates how increasing the intake of cruciferous vegetables, which are rich in isothiocyanates (ITCs), can help reduce the recurrence and progression of non-muscle invasive bladder cancer (NMIBC). Patients will participate in a dietary intervention called POW-R-Health, designed to boost their consumption of these vegetables and subsequently increase urinary ITC levels. The study aims to sustain these elevated levels over time to maximize their potential anticancer effects. By focusing on dietary changes, the research seeks to provide a non-invasive approach to managing bladder cancer.
Why it matters
Potential benefit: If successful, this research could offer a dietary strategy to significantly reduce the chances of bladder cancer recurrence and progression for patients.
How similar studies have gone: Previous studies have shown promising results with dietary interventions using cruciferous vegetables in cancer prevention, suggesting potential for success in this approach.
Where this research is happening
-
Roswell Park Cancer Institute Corp
Buffalo, United States Active
Researchers
- Principal investigator: Yeary, Karen Hye-Cheon Kim — Roswell Park Cancer Institute Corp
- Study coordinator: Yeary, Karen Hye-Cheon Kim
Related research
Other NIH-funded projects on the same topics.
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Cruciferous vegetable program to lower bladder cancer recurrence
This project will see if a simple program to boost cruciferous vegetable intake can help people with early-stage (non-muscle invasive) bladder cancer lower the chance their cancer comes back or gets worse.
-
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A research effort will look at why keloids come back after surgery, especially in African American patients, using comprehensive molecular data from patient samples.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.