Using CRISPR to understand how genes control cell behavior
CRISPR-mediated Chemical Genetics Define Transcription Factor Gene Networks and Mechanisms of Control
This study is looking at how certain proteins that control gene activity respond to different signals, using a new technique to quickly break them down so we can see how this affects gene behavior; the goal is to help us understand diseases like cancer and neurological disorders better, which could lead to new treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project ID | NIH-10873753 on NIH RePORTER |
What this research studies
This research investigates how specific proteins called transcription factors regulate gene expression in response to various signals. By employing CRISPR technology, the study aims to rapidly degrade these transcription factors, allowing researchers to observe immediate changes in gene activity. This approach overcomes previous limitations of slower methods, enabling a clearer understanding of how disruptions in these proteins can lead to diseases like cancer and neurological disorders. Patients may benefit from insights gained about the mechanisms of their conditions and potential new therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cancers or genetic disorders related to transcription factor activity.
Not a fit: Patients with conditions unrelated to transcription factor regulation may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases linked to transcription factor dysfunction, such as cancer.
How similar studies have performed: Other research using CRISPR technology has shown promise in understanding gene regulation, indicating that this approach could yield valuable insights.
Where this research is happening
Bronx, United States
- Albert Einstein College of Medicine — Bronx, United States (Active)
Researchers
- Principal investigator: Stengel, Kristy — Albert Einstein College of Medicine
- Study coordinator: Stengel, Kristy
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.