Using CRISPR to improve genetic testing by removing pseudogenes
Official title: CRISPR-based depletion method for resolving pseudogene contamination in Next Generation Sequencing (NGS) based genetic testing
Funded at Jumpcode Genomics · NIH-11066297 · Data updated 2026-11-12
This study is looking at how to make genetic tests for newborns even better by using a special tool called CRISPR to remove confusing bits of DNA that can mess up the results, helping doctors find any serious genetic issues more accurately.
Quick facts
| Grant type | Sbir 1 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Jumpcode Genomics NIH-funded |
| Lab location | 1 site (San Diego, UNITED STATES) |
| Project start | March 3, 2025 |
| Project end | February 28, 2026 |
| Funding year | 2025 |
| Award (this year) | $383,748 |
| NIH project number | 1R43HG014080-01 |
| Project ID | NIH-11066297 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are newborns undergoing genetic screening for inherited diseases.
✕Less likely to help
Patients with genetic conditions that are not included in the newborn screening panel may not benefit from this research.
What this research studies
This research focuses on enhancing next-generation sequencing (NGS) genetic tests by using CRISPR technology to eliminate pseudogenes, which are non-functional DNA sequences that can interfere with accurate genetic analysis. By degrading these pseudogenes, the study aims to improve the detection of disease-causing genetic mutations, particularly in newborn screening tests. The approach involves applying CRISPR-based depletion methods to refine library preparation workflows, thereby increasing the sensitivity and specificity of genetic tests. This could lead to more accurate diagnoses and better patient outcomes.
Why it matters
Potential benefit: If successful, this research could significantly improve the accuracy of genetic testing, leading to better diagnosis and treatment options for patients with genetic disorders.
How similar studies have gone: Previous studies have shown promise in using CRISPR technology for genetic applications, indicating that this approach could be effective.
Where this research is happening
-
Jumpcode Genomics
San Diego, United States Active
Researchers
- Principal investigator: Brown, Keith — Jumpcode Genomics
- Study coordinator: Brown, Keith
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.