Using CRISPR to create heart cells for repairing heart damage
CRISPR-induced cardiovascular progenitor cells to repair myocardial infarction
['FUNDING_R01'] · UNIVERSITY OF CINCINNATI · NIH-10802361
This study is exploring how a special technology called CRISPR can change certain cells into heart repair cells that might help heal damage from heart attacks, with the hope of improving recovery for patients like you.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CINCINNATI (nih funded) |
| Locations | 1 site (CINCINNATI, UNITED STATES) |
| Trial ID | NIH-10802361 on ClinicalTrials.gov |
What this research studies
This research investigates the use of CRISPR technology to convert cells into cardiovascular progenitor cells (CPCs) that can help repair damage caused by heart attacks. By directly manipulating genes, the researchers aim to create cells that can regenerate heart tissue and improve heart function. The study focuses on understanding how these reprogrammed cells can effectively promote new blood vessel formation and heart muscle regeneration. Patients may benefit from advancements in heart repair techniques that could lead to better recovery outcomes after myocardial infarction.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced a myocardial infarction and are seeking new treatment options for heart repair.
Not a fit: Patients with non-cardiovascular conditions or those who have not experienced a heart attack may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that significantly improve heart repair and recovery after heart attacks.
How similar studies have performed: Previous research has shown promising results using similar gene-editing approaches for cardiac repair, indicating potential for success in this novel application.
Where this research is happening
CINCINNATI, UNITED STATES
- UNIVERSITY OF CINCINNATI — CINCINNATI, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WANG, YIGANG — UNIVERSITY OF CINCINNATI
- Study coordinator: WANG, YIGANG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: cardiovascular disorder, Cardiovascular Diseases