Using CRISPR to analyze microbial genetic diversity
Developing CRISPR repeats as a means of phylogenetically profiling metagenomic data
This study is working on a new way to understand the tiny living things in our environment by looking at special genetic markers in microbes, which could help us learn more about the different types of microbes that exist and how they interact with each other.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Maryland, College Park NIH-funded |
| Lab location | 1 site (College Park, United States) |
| Project ID | NIH-10704753 on NIH RePORTER |
What this research studies
This research focuses on developing a new computational method to analyze metagenomic data, specifically using the CRISPR-Cas system found in many microbes. By examining the unique repeat sequences in CRISPR arrays, the researchers aim to uncover detailed information about the genetic diversity and composition of microbial communities. The approach involves creating a probabilistic model to predict community profiles based on CRISPR data, which will be tested against existing methods using both simulated and real environmental samples.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions influenced by microbial communities, such as gastrointestinal disorders or infections.
Not a fit: Patients with conditions unrelated to microbial diversity or those who do not have CRISPR-containing microbes in their microbiomes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of microbial ecosystems, leading to improved diagnostics and treatments for diseases linked to microbial imbalances.
How similar studies have performed: Previous research has shown promise in using CRISPR for microbial profiling, indicating that this approach could yield valuable insights.
Where this research is happening
College Park, United States
- Univ of Maryland, College Park — College Park, United States (Active)
Researchers
- Principal investigator: Johnson, Philip Lee Falk — Univ of Maryland, College Park
- Study coordinator: Johnson, Philip Lee Falk
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.