Using CRISPR technology to understand and control antibiotic resistance in bacteria
Official title: CRISPR-Cas-directed transposition in Tn7-like elements
Funded at Cornell University · NIH-11019837 · Data updated 2026-11-12
This study is looking at how some bacteria can become resistant to antibiotics and how we can use a special technology called CRISPR to change their genes, which could help us find better ways to treat infections that are hard to cure.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cornell University NIH-funded |
| Lab location | 1 site (Ithaca, United States) |
| Project start | February 1, 2024 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $336,166 |
| NIH project number | 5R35GM152260-02 |
| Project ID | NIH-11019837 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from infections caused by antibiotic-resistant bacteria.
✕Less likely to help
Patients with infections that are not caused by bacterial pathogens or those who do not have antibiotic resistance issues may not benefit from this research.
What this research studies
This research investigates how certain mobile genetic elements in bacteria can acquire antibiotic resistance and how they can be manipulated using CRISPR technology. By studying Tn7-like elements and their interaction with CRISPR-Cas systems, the research aims to develop new tools for precise genetic editing in bacteria. This could lead to better strategies for combating antibiotic-resistant infections. The approach involves understanding the mechanisms of these elements and their potential applications in both bacterial communities and human therapies.
Why it matters
Potential benefit: If successful, this research could lead to innovative methods for treating antibiotic-resistant bacterial infections.
How similar studies have gone: Previous research has shown promise in using CRISPR technology for genetic editing, suggesting that this approach could lead to significant advancements in understanding and controlling antibiotic resistance.
Where this research is happening
-
Cornell University
Ithaca, United States Active
Researchers
- Principal investigator: Peters, Joseph E — Cornell University
- Study coordinator: Peters, Joseph E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.