Using CRISPR technology to understand and control antibiotic resistance in bacteria
CRISPR-Cas-directed transposition in Tn7-like elements
This study is looking at how some bacteria can become resistant to antibiotics and how we can use a special technology called CRISPR to change their genes, which could help us find better ways to treat infections that are hard to cure.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cornell University NIH-funded |
| Lab location | 1 site (Ithaca, United States) |
| Project ID | NIH-11019837 on NIH RePORTER |
What this research studies
This research investigates how certain mobile genetic elements in bacteria can acquire antibiotic resistance and how they can be manipulated using CRISPR technology. By studying Tn7-like elements and their interaction with CRISPR-Cas systems, the research aims to develop new tools for precise genetic editing in bacteria. This could lead to better strategies for combating antibiotic-resistant infections. The approach involves understanding the mechanisms of these elements and their potential applications in both bacterial communities and human therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from infections caused by antibiotic-resistant bacteria.
Not a fit: Patients with infections that are not caused by bacterial pathogens or those who do not have antibiotic resistance issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative methods for treating antibiotic-resistant bacterial infections.
How similar studies have performed: Previous research has shown promise in using CRISPR technology for genetic editing, suggesting that this approach could lead to significant advancements in understanding and controlling antibiotic resistance.
Where this research is happening
Ithaca, United States
- Cornell University — Ithaca, United States (Active)
Researchers
- Principal investigator: Peters, Joseph E — Cornell University
- Study coordinator: Peters, Joseph E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.