Using CRISPR technology to improve gene editing in human cells
Analysis of homolog-based CRISPR editing in somatic cells
This study is looking at ways to make gene editing more accurate using CRISPR technology, which could help improve treatments for genetic disorders and benefit patients by making therapies more effective.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10893381 on NIH RePORTER |
What this research studies
This research investigates how to enhance the precision of gene editing in somatic cells using CRISPR technology. It focuses on understanding the mechanisms of DNA repair, particularly the homology directed repair (HDR) pathway, which is crucial for accurate genome editing. By developing new genetic tools, the research aims to shift the balance from a less precise repair method to a more accurate one, potentially improving the effectiveness of gene therapies for various conditions. Patients may benefit from advancements in gene editing that could lead to more effective treatments for genetic disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic disorders that could be treated through precise gene editing techniques.
Not a fit: Patients with conditions that do not involve genetic mutations or those who are not eligible for gene therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective gene therapies for genetic disorders, improving patient outcomes.
How similar studies have performed: Other research has shown promise in using CRISPR technology for gene editing, indicating that this approach has the potential for significant advancements in the field.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Bier, Ethan — University of California, San Diego
- Study coordinator: Bier, Ethan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.