Using corticosteroids to improve swallowing after breathing tube removal in older patients
Randomized Trial of Corticosteroids for Post-Extubation Aspiration
This study is looking at whether giving corticosteroids can help older patients who have been on a breathing machine and are having trouble swallowing, by reducing swelling in their throat and making it easier for them to eat and drink safely after they come off the machine.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-10947628 on NIH RePORTER |
What this research studies
This research investigates the use of corticosteroids to reduce complications related to swallowing difficulties in older patients who have been on mechanical ventilation due to acute respiratory failure. The study aims to determine if corticosteroids can decrease laryngeal swelling, which is a common issue that can lead to aspiration and other serious health problems after extubation. By comparing outcomes between patients receiving corticosteroids and those who do not, the research seeks to find a more effective treatment approach for this vulnerable population. Patients will be monitored for improvements in swallowing function and overall health outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults (65 years and older) who have experienced acute respiratory failure and require mechanical ventilation.
Not a fit: Patients who are younger than 65 years or those who do not have swallowing difficulties following extubation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved swallowing function and reduced complications for older patients recovering from respiratory failure.
How similar studies have performed: Previous research has indicated that corticosteroids may help reduce inflammation in similar patient populations, suggesting potential for success in this approach.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Moss, Marc — University of Colorado Denver
- Study coordinator: Moss, Marc
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.