Using converted neurons to study ALS and frontotemporal dementia
Official title: Directly Converted Neurons as a Novel Cellular Model for ALS and FTD
Funded at Washington University · NIH-10952676 · Data updated 2026-11-12
This study is exploring a new way to understand neurodegenerative diseases like ALS and frontotemporal dementia by turning skin cells into brain cells while keeping their original age, which could help researchers find better treatments and learn more about these conditions.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | July 15, 2024 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $427,625 |
| NIH project number | 1R21NS139222-01 |
| Project ID | NIH-10952676 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with ALS or frontotemporal dementia, particularly those with familial forms of these diseases.
✕Less likely to help
Patients with neurodegenerative diseases not related to ALS or frontotemporal dementia may not benefit from this research.
What this research studies
This research investigates a new method of modeling neurodegenerative diseases like ALS and frontotemporal dementia by converting skin cells into neurons. Unlike traditional methods that erase the age of cells, this approach preserves the original cellular age, which is crucial for understanding these diseases. The researchers will study both familial and sporadic cases of ALS to identify specific neurodegenerative features and test potential treatments. This innovative technique aims to provide deeper insights into the mechanisms of these conditions and how they can be addressed.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential therapies for ALS and frontotemporal dementia.
How similar studies have gone: Previous research has shown success in using direct neuronal conversion to model other neurodegenerative diseases, indicating potential for this novel approach.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Miller, Timothy M. — Washington University
- Study coordinator: Miller, Timothy M.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.