Using controlled-release microbeads to replace animal serum in cell cultures
Official title: Controlled-release Microbeads to Replace Growth Factors in Fetal Bovine Serum
Funded at Stemcultures, LLC · NIH-10806135 · Data updated 2026-11-12
This study is testing a new device that helps grow eye cells more reliably without using animal products, which could make it easier to develop better treatments for eye conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stemcultures, LLC NIH-funded |
| Lab location | 1 site (Rensselaer, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $826,379 |
| NIH project number | 5R42GM142345-03 |
| Project ID | NIH-10806135 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals interested in advancements in stem cell therapies, particularly those related to retinal diseases.
✕Less likely to help
Patients who are not involved in or do not have conditions related to retinal health or stem cell therapies may not benefit from this research.
What this research studies
This research focuses on developing a bioengineered device that can release human growth factors in a controlled manner, aiming to replace fetal bovine serum (FBS) in cell culture. FBS has been widely used for over a century but poses challenges such as variability, contamination, and ethical concerns. By utilizing a Defined Insert for Sustainable Culture (DISCTM) device, the project seeks to enhance the reproducibility of human retinal pigment epithelial (RPE) cell growth, which is crucial for advancements in stem cell therapies. The approach aims to improve cell culture conditions while reducing reliance on animal products.
Why it matters
Potential benefit: If successful, this research could lead to more reliable and ethical methods for growing human cells, which may enhance the development of therapies for various conditions.
How similar studies have gone: While the use of controlled-release systems in cell culture is an emerging field, similar approaches have shown promise in improving cell growth conditions, indicating potential for success.
Where this research is happening
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Stemcultures, LLC
Rensselaer, United States Active
Researchers
- Principal investigator: Stern, Jeffrey H — Stemcultures, LLC
- Study coordinator: Stern, Jeffrey H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.