Using computer technology to improve the diagnosis of heart transplant rejection
Computer-Assisted Histologic Evaluation of Cardiac Allograft Rejection
This study is looking at how a new computer system can help doctors better diagnose heart transplant rejection by analyzing tissue samples, which could lead to improved care for patients who have received a heart transplant.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10687842 on NIH RePORTER |
What this research studies
This research focuses on enhancing the accuracy of diagnosing cardiac allograft rejection through advanced computer-assisted histologic evaluation. By utilizing a novel computer-assisted grading system, the study aims to provide more precise analysis of endomyocardial biopsy samples, which are critical for assessing transplant rejection. The approach leverages computational pathology techniques to improve diagnostic performance compared to traditional methods used by pathologists. This could lead to better treatment decisions and outcomes for patients undergoing heart transplantation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have undergone heart transplantation and are at risk for cardiac allograft rejection.
Not a fit: Patients who have not received a heart transplant or those with other unrelated cardiac conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate diagnoses of heart transplant rejection, reducing the risks of both over-treatment and under-treatment for patients.
How similar studies have performed: Previous research in computational pathology has shown promising results, indicating that this approach could significantly improve diagnostic accuracy in similar contexts.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Margulies, Kenneth Ber — University of Pennsylvania
- Study coordinator: Margulies, Kenneth Ber
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.