Using computer simulations to improve treatment for heart diseases through personalized medicine.
Official title: Computational simulation of the potential improvement in clinical outcomes of cardiovascular diseases with the use of a personalized predictive medicine approach
Funded at Johns Hopkins University · NIH-10757046 · Data updated 2026-11-12
This study is looking at how customizing heart disease treatments based on each person's unique needs can lead to better health outcomes, using computer simulations to compare these personalized plans with standard treatments.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | January 1, 2023 |
| Project end | December 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $122,813 |
| NIH project number | 5R21HL161685-02 |
| Project ID | NIH-10757046 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with cardiovascular diseases who may benefit from personalized treatment approaches.
✕Less likely to help
Patients with cardiovascular diseases who are not interested in personalized treatment strategies or those who do not meet the eligibility criteria may not benefit from this research.
What this research studies
This research investigates how personalized medicine can enhance clinical outcomes for patients with cardiovascular diseases by utilizing computer simulations. By analyzing data from approximately 130 previous clinical trials, the study aims to predict the benefits of tailoring treatment plans to individual patient characteristics rather than applying a one-size-fits-all approach. The methodology involves comparing outcomes from personalized treatment strategies against standard treatment protocols to assess potential improvements in patient care.
Why it matters
Potential benefit: If successful, this research could lead to more effective and individualized treatment options for patients with cardiovascular diseases.
How similar studies have gone: Previous research has shown promise in using personalized medicine approaches, but this specific application through computer simulations is relatively novel.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Manlhiot, Cedric — Johns Hopkins University
- Study coordinator: Manlhiot, Cedric
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.