Using computer methods to understand how genes are regulated and linked to diseases
Official title: Computational Methods for Investigating the Genetics of Gene Regulation
Funded at Duke University · NIH-11135458 · Data updated 2026-11-12
This study is looking at how changes in our genes can affect how our genes work, with the goal of helping to find better ways to diagnose complex diseases that don’t have clear genetic answers, so patients can get the care they need.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | August 15, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $382,173 |
| NIH project number | 5R35GM150404-03 |
| Project ID | NIH-11135458 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with complex diseases that have not yet been genetically diagnosed.
✕Less likely to help
Patients with well-defined genetic conditions that are already diagnosed may not benefit from this research.
What this research studies
This research focuses on developing advanced computational methods to analyze genetic data related to gene regulation. By investigating how certain genetic variants affect gene expression, the research aims to identify the underlying causes of complex diseases. The approach includes analyzing data from various experimental techniques, including CRISPR, to uncover relationships between genes and their regulatory elements. Patients may benefit from improved diagnostic rates for diseases that currently lack clear genetic explanations.
Why it matters
Potential benefit: If successful, this research could lead to better diagnosis and understanding of complex diseases, potentially improving treatment options for patients.
How similar studies have gone: Other research has shown promise in using computational methods to analyze gene regulation, indicating that this approach could yield significant insights.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Majoros, William — Duke University
- Study coordinator: Majoros, William
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.