Using computer methods to understand how genes are regulated and linked to diseases
Computational Methods for Investigating the Genetics of Gene Regulation
['FUNDING_OTHER'] · DUKE UNIVERSITY · NIH-11135458
This study is looking at how changes in our genes can affect how our genes work, with the goal of helping to find better ways to diagnose complex diseases that don’t have clear genetic answers, so patients can get the care they need.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DUKE UNIVERSITY (nih funded) |
| Locations | 1 site (DURHAM, UNITED STATES) |
| Trial ID | NIH-11135458 on ClinicalTrials.gov |
What this research studies
This research focuses on developing advanced computational methods to analyze genetic data related to gene regulation. By investigating how certain genetic variants affect gene expression, the research aims to identify the underlying causes of complex diseases. The approach includes analyzing data from various experimental techniques, including CRISPR, to uncover relationships between genes and their regulatory elements. Patients may benefit from improved diagnostic rates for diseases that currently lack clear genetic explanations.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with complex diseases that have not yet been genetically diagnosed.
Not a fit: Patients with well-defined genetic conditions that are already diagnosed may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better diagnosis and understanding of complex diseases, potentially improving treatment options for patients.
How similar studies have performed: Other research has shown promise in using computational methods to analyze gene regulation, indicating that this approach could yield significant insights.
Where this research is happening
DURHAM, UNITED STATES
- DUKE UNIVERSITY — DURHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MAJOROS, WILLIAM — DUKE UNIVERSITY
- Study coordinator: MAJOROS, WILLIAM
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.