Using computational tools to understand the genetics, biology, and clinical aspects of human disease
Computational approaches to advance genomic, biological and clinical understandings of human disease
This project uses computer analysis of large genetic and medical datasets to reveal how DNA changes affect disease risk and treatment for people with common and rare conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11317059 on NIH RePORTER |
What this research studies
Researchers at Mount Sinai will analyze large-scale genetic and clinical datasets and build new statistical tools to better estimate the disease risk of specific genetic variants. They will apply approaches like Mendelian randomization to suggest which traits may cause disease and study how natural selection has shaped disease-related genes. The team will also work on predicting drug side effects from genomic data and improving interpretation of clinical genetic test results.
Who could benefit from this research
Good fit: People who have had genetic testing or who can share de-identified genetic and health record data would be the best fit to contribute to this research.
Not a fit: Patients without genetic testing or with conditions driven mainly by non-genetic factors may not see direct benefits in the near term.
Why it matters
Potential benefit: If successful, this work could help patients by clarifying which genetic variants raise disease risk, pointing to more effective treatments, and reducing adverse drug effects.
How similar studies have performed: Large-scale genomic analyses and Mendelian randomization studies have previously found disease genes and causal links, but this project applies new computational methods and data combinations that are partly novel.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Do, Ron — Icahn School of Medicine at Mount Sinai
- Study coordinator: Do, Ron
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.