Using cold technology to relieve pain after knee surgery
Neural Ice Technology for Treatment of Pain
['FUNDING_SBIR_2'] · BRIXTON BIOSCIENCES, INC. · NIH-11006862
This study is testing a new way to help people manage pain after knee surgery without using opioids, by using a special freezing technique on certain nerves to provide lasting relief, making it easier and safer for patients.
Quick facts
| Phase | ['FUNDING_SBIR_2'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BRIXTON BIOSCIENCES, INC. (nih funded) |
| Locations | 1 site (Cambridge, UNITED STATES) |
| Trial ID | NIH-11006862 on ClinicalTrials.gov |
What this research studies
This research focuses on developing a new method to manage pain following total knee arthroplasty (TKA) without relying on opioids. The approach involves a technique called cryoneurolysis, which uses very low temperatures to freeze specific nerves, providing long-lasting pain relief. The goal is to create an injectable version of this treatment that is easier to administer and more effective than current methods. By reducing the need for opioid medications, this research aims to address the growing opioid crisis while improving patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults undergoing total knee arthroplasty due to severe osteoarthritis or rheumatic arthritis.
Not a fit: Patients who are not undergoing knee surgery or those with contraindications to cryoneurolysis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a safe, effective, and non-opioid method for managing postoperative pain in knee surgery patients.
How similar studies have performed: Previous research has shown promise in using cryoneurolysis for pain management, indicating potential success for this novel injectable approach.
Where this research is happening
Cambridge, UNITED STATES
- BRIXTON BIOSCIENCES, INC. — Cambridge, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SIDOTI, CHARLES — BRIXTON BIOSCIENCES, INC.
- Study coordinator: SIDOTI, CHARLES
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.