Using cold stored platelets to improve blood vessel stability after trauma
The Therapeutic Potential of Cold Stored Platelets in Regulating Vascular Instability in Trauma
This study is looking at whether using cold stored platelets can help improve blood vessel healing in patients who have had serious injuries, like traumatic brain injuries, by comparing the effects of platelets kept at cooler temperatures to those stored at room temperature.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10652299 on NIH RePORTER |
What this research studies
This research investigates the use of cold stored platelets as a potential treatment to enhance vascular stability in patients who have experienced trauma, particularly traumatic brain injury. The study aims to compare the effects of platelets stored at lower temperatures (4°C) versus the standard storage temperature (22°C) on the healing and stability of blood vessels. By understanding how these platelets function in regulating vascular integrity, the research seeks to improve outcomes for severely injured patients. The methodology includes transfusing cold stored platelets to assess their impact on vascular permeability and inflammation in trauma cases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 1-44 who have suffered severe trauma, particularly those with traumatic brain injuries.
Not a fit: Patients with stable conditions or those who do not require platelet transfusions for their injuries may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved survival rates and recovery for trauma patients by enhancing the effectiveness of platelet transfusions.
How similar studies have performed: Previous research has indicated that cold stored platelets may offer advantages over traditional storage methods, suggesting a promising avenue for further exploration.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Pati, Shibani — University of California, San Francisco
- Study coordinator: Pati, Shibani
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.