Using clozapine to reduce violence in people with schizophrenia
Official title: 5/7 Clozapine for the Prevention of Violence in Schizophrenia: a Randomized Clinical Trial
Funded at Nathan S. Kline Institute for Psych Res · NIH-10876287 · Data updated 2026-11-12
This study is looking at whether clozapine, a medication for schizophrenia, can help reduce the chances of violent behavior in people who are at high risk, and it’s for individuals with schizophrenia who might benefit from a new treatment option.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Nathan S. Kline Institute for Psych Res NIH-funded |
| Lab location | 1 site (Orangeburg, United States) |
| Project start | July 1, 2021 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $203,625 |
| NIH project number | 5R01MH120185-04 |
| Project ID | NIH-10876287 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with schizophrenia who exhibit a high risk of violent behavior.
✕Less likely to help
Patients with schizophrenia who are not at risk for violence or those who do not meet the study's inclusion criteria may not benefit from this research.
What this research studies
This research investigates the effectiveness of clozapine, an antipsychotic medication, in reducing the risk of violent behavior among individuals diagnosed with schizophrenia who are at high risk for violence. The study will involve a randomized clinical trial across seven sites, where participants will receive either clozapine or standard treatment for a duration of 24 weeks. By focusing on real-world community settings, the research aims to provide more generalizable results compared to previous studies. The primary goal is to measure the time until any violent acts occur among participants, contributing valuable data to improve treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatment options for reducing violence in individuals with schizophrenia, ultimately improving their quality of life and reducing stigma.
How similar studies have gone: Previous studies have suggested that clozapine may be more effective than other antipsychotics in reducing aggression, but this trial aims to provide robust evidence through a well-designed randomized clinical trial.
Where this research is happening
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Nathan S. Kline Institute for Psych Res
Orangeburg, United States Active
Researchers
- Principal investigator: Lindenmayer, Jean-Pierre — Nathan S. Kline Institute for Psych Res
- Study coordinator: Lindenmayer, Jean-Pierre
Related research
Other NIH-funded projects on the same topics.
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Clozapine to reduce violence in schizophrenia
A large study will compare clozapine to usual treatment to see if it lowers violent acts in people with schizophrenia who are at high risk of violence.
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Clozapine to reduce violent behavior in people with schizophrenia
This compares clozapine with usual care to try to lower the chance of violent acts in people with schizophrenia who are at higher risk.
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Clozapine to Help Prevent Violence in Schizophrenia
This project looks at whether a medication called clozapine can help people with schizophrenia reduce violent behavior.
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Clozapine to prevent violence in schizophrenia
This project explores if a medication called clozapine can help reduce violent behavior in people living with schizophrenia.
-
Clozapine to reduce violence in people with schizophrenia
This trial will compare clozapine with usual antipsychotic care to see whether clozapine lowers the chance of violent acts in people with schizophrenia who are at high risk.
-
Clozapine to prevent violent behavior in people with schizophrenia
This trial will compare clozapine with usual treatment to see if it lowers the chance of violent acts in people with schizophrenia who are at high risk.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.